Brain-on-Chips

Microglia-on-a Chip
Microglia-on-a Chip
We developed a microglial AD model, which could reconstruct the in vivo signature of microglial recruitment along the gradient of soluble and co-localization on plaques (Sci. Rep. 2013;3:1823).
We are currently expanding its applications to drug assessment and interactions with other brain and blood cells in AD.

 

Brain tumor-on-a Chip
Brain tumor-on-a Chip
We developed microfluidic circuits spontaneously patterning Glioblastoma and brain endothelial cells by surface tension and studied the effect of heterogeneous cell-cell interactions between the brain tumour and the endothelial cells (Nat. Comm. 2014 under revision).
We are currently improving the circuit by combining with monitoring sensors.

 

3D BBB-on-a Chip
3D BBB-on-a Chip
We developed a tube-like 3D BBB model constructed with brain endothelial cells and demonstrated pathological destruction of BBB in neuroinflammation and ischemia model (Nat. Method 2014 submitted).
We are currently improving the model by co-culturing with other brain cells.

 

Neuron-on-a Chip
Neuron-on-a Chip
We developed a microfluidic platform composed of three distinct chambers to form dual-layered neurons and examined neuronal tau uptake, transport, and release across the layers to identify specific tau species responsible for propagation of AD (Nat. Neuroscience 2014 submitted).
We are currently expanding its applications to various comparative assays for neurons.