Journals and Proceedings

  • Representative Publications

H. Cho, J.H. Seo, K.H.K. Wong, Y. Terasaki, J. Park, K. Bong, K. Arai, E.H. Lo, D. Irimia, “Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology,” Sci. Rep. 2015; 5:15222 (attached)

H. Cho, T. Hashimoto, E.A. Wong, L. Zhao, Y. Hori, L.B, Wood, K.M. Haigis, B.T. Hyman, D. Irimia, “Microfluidic Chemotaxis Platform for Differentiating the Distinct Roles of Soluble and Bound Amyloid-β on Microglial Accumulation,” Sci. Rep. 2013; 3:1823 (attached)

H. Cho, E. -C. Yeh, R. Sinha, T.A. Laurence, J.P. Bearinger, L.P. Lee, “Single­Step Nanoplasmonic VEGF165 Aptasensor for Cancer Diagnosis,” ACS Nano 2012; 6:7607-7614 (attached)

H. Cho, H.Y. Kim, J.Y. Kang, T.S. Kim, “How the Capillary Burst Microvalve Works,” J. Colloid and Interface Science 2007; 306:379-385 (attached)

 
  • 2017

25. J. H. Shin, M. H. Hwang, G. E. Jo, K. S. Kim, H. Nam, S. M. Baek, C. M. Yoo, H. J. Moon, J. H. Kim, H. Cho, H. Choi, “Spine-on-a-chip; Human annulus fibrosus degeneration model for simulating the severity of IVD,” Biomicrofluidics 2017 (accepted)

24. J. Park, I. Wetzel, D. Dreau, H. Cho,  “Three-dimensional Miniaturization of Human Organs for Drug Discoverys,” Adv. Health. Mater. 2017,3:170051 (cover image)  

23. E. Reátegui, A. Khankel, B. Jalali, E. Wong, H. Cho, C. N. Serhan, J. Dalli, H. Elliot, D. Irimia “Microscale Platform for the Profiling of Start and Stop Signals Coordinating Human Neutrophil Swarming,” Nat. Biomed Engr 2017,1:0094 (cover image)  

Under review or revision

  • J. Park, I. Marriott, D. Dreau, D. Y. Kim, R. E. Tanzi, H. Cho, Nat. Neurosci revision
  • H. Cho et al., Nat. Comm. revision
  • Zare, E. Cutler, H. Cho, APL revision
  • X. Du, W. Li, G. Du, H. Cho, M. Yu, Q. Fang, L. P. Lee, J. Fang, submitted to APL
  • J. Park, I. Wetzel, S. H. Baik, I. Mook-Jung, D. Irimia, H. Cho, submitted to LOC

H. Cho, “Construction of human 3D brain model of Alzheimer’s disease and study of microglial inflammatory activity leading to neuronal damage,” 3rd Organ-on-a-Chip World Congress & 3D-Culture, Boston, MA, USA, July 10-11, 2017 (Organ-on-a-Chip and Body-on-a-Chip 2017) (invited talk)

J. Park, I. Wetzel, H. Cho, “Mimicry of Neuroinflammatory Environment in Alzheimer’s Disease and Discovery of Microglial Modulation in Neutrophil Recruitment to Central Nervous System,” TERMIS-AM annual conference, Charlotte, NC, USA, Dec. 3-6, 2017 (oral presentation)

J. Park, Ram Ganapathi, H. Cho, “Cooperative role of glioma and microglia migration in tumor mimicking microenvironment through the paracrine PAI-1/IL6 signaling,” Annual Symposium: Charlotte Biomedical Science and Engineering, Charlotte, NC, USA, May 5, 2017 (oral presentation)

J. Park, D. Dréau, D. Y. Kim, R. E. Tanzi, H. Cho, “Neuron-Glia Interactions in 3D Organotypic Human Alzheimer’s Disease Brain Model,” Gordon Research Conference: Glial Biology: Functional Interactions Among Glia & Neurons, Ventura, CA, USA, Mar. 5-10, 2017

  • 2016

Park, D.Y. Kim, R.E. Tanzi, H. Cho, “Microglial Activation and Neuronal Loss on Recapitulated 3D Human 3D Alzheimer’s Disease Brain Model,” the Society for Neuroscience’s 44th annual meeting (Neuroscience 2016), San Diego, CA, USA, Nov. 12-16, 2016

Reátegui, A. Khankel, B. Jalali, E. Wong, H. Cho, C. N. Serhan, J. Dalli, H. Elliot, D. Irimia “Inter-Cellular Signals during Human Neutrophil Swarming,” the Biomedical Engineering Society Annual Meeting (BMES2016), Minneapolis, WA, USA, Oct. 5-8, 2016

  • 2015

22. K.W. Bong, J.J. Kim, H. Cho, E. Lim, P. Doyle, D. Irimia, “Synthesis of Cell-Adhesive Anisotropic Multifunctional Particles by Stop Flow Lithography and Streptavidin-Biotin Interactions,” Langmuir 2015, ;8:13165-13171 

21. H. Cho, J.H. Seo, K.H.K. Wong, Y. Terasaki, J. Park, K. Bong, K. Arai, E.H. Lo, D. Irimia, “Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology,” Sci. Rep. 2015; 5:15222

20. S. Takedaa, S. Wegmanna, H. Cho, S. L. DeVosa, C. Comminsa, A. D. Roea, S. B. Nichollsa, G. A. Carlsonc, R. Pitstickc, C. K. Nobuharaa, I. Costantinoa, M. P. Froscha, D. J. Müllerd, D. Irimiab, B. T. Hyman, “Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau species derived from tau-transgenic mouse and human Alzheimer’s disease brain,” Nat. Comm. 2015; 6:8496 

19. Y. Hori, S. Takeda, H. Cho, S. Wegmann, T. M. Shoup, K. Takahashi, D. Irimia, D. R. Elmaleh, B. T. Hyman, E. Hudry, “FDA approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer’s disease,” JBC 2015, 2090: 1966-1978

  • 2014

18. H. Cho*, B. Hamza* (*equal contribution), E.A. Wong, D. Irimia, “On-demand, Competing Gradient Arrays for Neutrophil Chemotaxis,” LOC 2014, 14:972-978

17. S. H. Baik, M.-Y. Cha, Y.-M. Hyun, H. Cho, B. Hamza, D. K. Kim, S.-H. Han, H. Choi, K. H. Kim, M. Moon, J. Lee, M. Kim, D. Irimia, I. M.-J., “Migration of Neutrophils Targeting Amyloid Plaques in Alzheimer’s Disease Mouse Model,” Neurobiology of Aging 2014, 35: 1286-1292

16. B. Hamza, S. Patel, E. Wong, H. Cho, J. Martel, D. Irimia, “Retrotaxis of Human Neutrophils during Mechanical Confinement inside Microfluidic Channels,” Integrative Biology 2014, 6:175-183

H. Cho et al., “Neutrophil Recruitment is Mediated by Soluble Factors from Microglia during Alzheimer’s Disease,” the Society for Neuroscience’s 44th annual meeting (Neuroscience 2014), Washington, DC, USA, Nov. 15-19, 2014

S. Takeda et al., “Neuron-to-neuron propagation of high-molecular-weight tau species derived from tau-transgenic mouse and human Alzheimer’s disease brain,” the Society for Neuroscience’s 44th annual meeting (Neuroscience 2014), Washington, DC, USA, Nov. 15-19, 2014

  •  2013

15. H. Cho et al, “Microfluidic Chemotaxis Platform for Differentiating the Distinct Roles of Soluble and Bound Amyloid-β on Microglial Accumulation,” Sci. Rep. 2013; 3:1823 

H. Cho, J. H. Seo, K. Wong, K. Bong, Yasukazu Terasaki, K. Arai, E. H. Lo, D. Irimia, “A Tube-shaped in vitro Blood-Brain-Barrier Model in Planar Microfluidics,” the Society for Neuroscience’s 43rd annual meeting (Neuroscience 2013), San Diego, CA, USA, Nov. 9-13, 2013

H. Cho, J. H. Seo, K. Wong, K. Bong, K. Arai, E. H. Lo, D. Irimia, “A Tube-shaped in vitro Blood-Brain-Barrier Model in Planar Microfluidics,” the Biomedical Engineering Society Annual Meeting (BMES2013), Seattle, WA, USA, Sep. 25-28, 2013 (oral presentation)

H. Cho, B. Hamza, E. Wong, D. Irimia, “Microfluidic Platform for On-Demand, Competitive, Large-Scale Chemotaxis Assays of Neutrophils,” the Biomedical Engineering Society Annual Meeting (BMES2013), Seattle, WA, USA, Sep. 25-28, 2013 (oral presentation)

  • 2012

14. H. Cho, E. -C. Yeh, R. Sinha, T.A. Laurence, J.P. Bearinger, L.P. Lee, “Single­Step Nanoplasmonic VEGF165 Aptasensor for Cancer Diagnosis,” ACS Nano 2012; 6:7607-7614 

H. Cho, T. Hashimoto, E. Wong, B.T. Hyman, D. Irimia, “Distinct Roles of Amyloid Beta on Microglial Accumulation in Alzheimer’s Disease,” the Biomedical Engineering Society Annual Meeting (BMES2012), Atlanta, GA, USA, Oct. 24-27, 2012 (oral presentation)

H. Cho, T. Hashimoto, E. Wong, B.T. Hyman, D. Irimia, “Ex vivo Alzheimer’s Disease Model Characterizing Accumulation of Microglia Cells Recruited by Soluble Amyloid Beta and Localized by Surface-Bound Amyloid Beta Fibrils,” the Society for Neuroscience’s 42nd annual meeting (Neuroscience 2012), New Orleans, LA, USA, Oct. 13-17, 2012

  • 2011

H. Cho, E. Hudrey, M. Toner, B.T. Hyman, D. Irimia, “Migration of Microglia Is Modulated by Amyloid Beta during the Progression of Alzheimer Disease,” the Biomedical Engineering Society Annual Meeting, (BMES2011), Hartford, MA, USA, Oct. 12-15, 2011 (oral presentation)

  • 2010

13. C.V. Pagba, S.M. Lane, H. Cho, S. Wachsmann-Hogiu, “Direct Detection of Aptamer-Thrombin Binding via Surface-Enhanced Raman Spectroscopy,” Journal of Biomedical Optics 2010; 15:0470061-0470068 

12. T. Kokalj*, H. Cho* (*equal contribution), M. Jenko, L.P. Lee, “Biologically-Inspired Porous Cooling Membrane Using Arrayed-Droplets Evaporation Biologically Inspired Cooling Membrane,” Applied Physics Letters 2010; 96:163703-163705 

11. H. Cho, R. Sinha, L.P. Lee, “Real-time and label-free aptasensor of VEGF for cancer diagnostics,” Cancer Research 2010; 7: 2721 

H. Cho, E.C. Yeh, R. Sinha, L.P. Lee, “Aptamer-Based Nanoplasmonic VEGF165 Sensor for Breast Cancer Diagnostics,” the Biomedical Engineering Society Annual Meeting, (BMES2010), Austin, TX, USA, Oct. 6-9, 2010 (oral presentation)

H. Cho, A. Kimteng, L.P. Lee, “Bidirectional Fluidic Diode,” 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2010) Groningen, the Netherlands, Oct. 3-7, 2010, (oral presentation)

T. Kokalj, H. Cho, M. Jenko, L.P. Lee, “Skin-Inspired Cooling Surface,” Lab-on-a-chip European Congress, Dublin, Ireland, May 25-26, 2010

H. Cho, R. Sinha, L.P. Lee, “Real-Time And Label-Free Aptasensor of VEGF for Cancer Diagnostics,” AACR 101st Annual Meeting, Washington, DC, USA, April 17-21, 2010, AACR highlighted

  •  2009

10. H. Cho, B. Lee, G.L. Liu, A. Agarwal, L.P. Lee, “Label Free and Highly Sensitive Biomolecular Detection Using SERS and Electrokinetic Preconcentration,” Lab Chip 2009; 9:3360-3363

9. D. Choi, T. Kang, H. Cho, Y. Choi, L.P. Lee, “Additional Amplifications of SERS via Optofluidic CD-Based Platform,” Lab Chip 2009; 9:239-243 

H. Cho, Y. Zhang, B. Lee, A. Kimteng, J.P. Beringer, B.R. Baker, T.A. Laurence, S.M. Lane, L.P. Lee, “Integrated Microfluidic Platform with Nanoplasmonic Aptasensor for On-Chip Lable-Free VEGF Detection in Dynamic Tumor Microenvironment,” 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2009), Jeju, Korea, November 1-5, 2009; 1482-1484

H. Cho, Y. Zhang, B.R. Baker, L.P. Lee, “Integrated Microfluidic Platform with Surface-Plasmonic Aptasensor for On-chip Label-free Detection of Cancer Markers from Cells,” 10th Annual UC Systemwide Bioengineering Symposium, Merced, CA, USA, June 19-21, 2009 (oral presentation) 

  • 2008

8. H. Cho, B.R. Baker, S. Wachsmann-Hogiu, C.V. Pagba, T.A. Laurence, S.M. Lane, L.P. Lee, J.B.H. Tok, “Aptamer-Based SERRS Sensor for Thrombin Detection,” Nano Letters 2008; 8:4386–4390 

7. B.C. Chang, S.H. Lim, H. Cho, S. Lee, J.H. Lee, Y.S. Hong, Y.N. Youn, Y.H. Park, “Preclinical Test of an Electro-Mechanical Implantable Left Ventricular Assist System,” Korea Circ. J. 2008; 38:7-11 

H. Cho, B.R. Baker, S. Wachsmann-Hogiu, C. Pagba, T. Laurence, S.M. Lane, L.P. Lee, J.B.H. Tok, “Detection of Thrombin by Aptamer-Based Surface Enhanced Resonance Raman Spectroscopy,” 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2008), San Diego, CA, USA, October 12-16, 2008:290-292

D. Choi, T. Kang, H. Cho, Y. Choi, L.P. Lee, “SERS Signal Amplification via Biofluidic-Adsorption Preconcentration in Optofluidic CD Platform,” 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2008), San Diego, CA, USA, October 12-16, 2008:964-966 

  • 2004-2007

6. H. Cho, H.Y. Kim, J.Y. Kang, T.S. Kim, “How the Capillary Burst Microvalve Works,” J. Colloid and Interface Science 2007; 306:379-385 

5. J.H. Kim, H.J. Shin, H.J. Cho, S.M. Kwak, H. Cho, T.S. Kim, J.Y. Kang, E.G. Yang, “A Microfluidic Protease Activity Assay Based on the Detection of Fluorescence Polarization,” Analytica Chimica Acta 2006; 577:171-177 

4. J.H. Lee, J.M. Jang, H. Cho, K.C. Han, T.S. Kim, J.Y. Kang, E.G. Yang, “Design and Characterization of Microfluidic Analysis System for RNA-Aminoglycoside Interactions,” Key Eng. Mater. 2005; 277-279:90-95 

3. H. Cho, H.-Y. Kim, J.-Y. Kang, S.-M. Kwak, T.-S. Kim, “Analysis and Evalution of Capillary Passive Valves in Microfluidic Systems Using a Centrifugal Force,” KIEE Int. Transact. EA 2004;4:155-159 

H. Cho, Y.T. Long, B. Lee, L.P. Lee, “Electrokinetic SERS Signal Amplification for Label-free Biomolecular Detection,” 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2007), Paris, France, October 7-11, 2007; 2:1182-1184 (oral presentation)

H. Cho, Y.T. Long, L.P. Lee, “Study on Biomolecules by Electrokinetic Concentration-Based SERS Amplification,” Biophysical Society’s 51st Annual Meeting, Baltimore, Maryland, USA, March 3-7, 2007

H. Cho, L.P. Lee, “A Novel Integrated Microfluidic SERS-CD with High-Throughput Centrifugal Cell Trapping Array for Quantitative Biomedicine,” 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2006), Tokyo, Japan, Nov. 5 – 9, 2006; 1:642

H. Cho, J. See, L.P. Lee, “A Novel Integrated Centrifugal Cell Trapping SERS-CD Platform for Quantitative Cell Analysis,” the Biomedical Engineering Society Annual Meeting (BMES2006), Chicago, IL, USA, Oct. 11-14, 2006

H. Cho, B. Kim, L.P. Lee, “Tunable Surface-Enhanced Raman Scattering Probes for Single Biomolecular Detections,” Biophysical Society’s 50th Annual Meeting, Salt Lake City, UT, USA, February 18-22, 2006

H. Cho, H.Y. Kim, J.Y. Kang, S.M. Park, T.S. Kim, “Modeling of Capillary Passive Valve and Fabrication Using SU-8,” the 6th Conference of HARMST, Gyeongju, Korea, June 6-13, 2005; 1:PD07

H. Cho, J.Y. Kang, S.M. Kwak, K. Hwang, J. Min, J. Lee, D. Yoon, T.S. Kim, “Integration of PDMS Microfluidic Channel with Silicon-Based Electromechanical Cantilever Sensor on a CD Chip,” IEEE 18th Int. Conf. on MEMS, Miami, FL, USA, March 2005; 18:698-701

J.Y. Kang, H. Cho, S.M. Kwak, D.S. Yoon, T.S. Kim, “Novel Particle Separation Using Spiral Channel and Centrifugal Force for Plasma Preparation from Whole Blood,” the 8th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2004), Malmo, Sweden, Sep. 26-30, 2004; 8:614-616

H. Cho, H.Y. Kim, J.Y. Kang, T.S. Kim, “Capillary Passive Valve in Microfluidic System,” the 7th Conference of Nanotech, Boston, MA, USA, March 7-11, 2004; 7:263-266 

  • 1999-2003

2. W.G. Kim, W.Y. Lee, B.H. Lee, H. Cho, “A Simplified Cardiopulmonary Bypass Technique for Animal Experiments on Implantable Ventricular Assist Devices,” Int. J. Artificial Organs 2002; 25:147-50

1. H. Cho, WG Kim, WY Lee, SM Kwak, SS Kim, JK Kim, JT Kim, MH Ryu, ES Ryu, KC Moon, BS Su, HJ Yu, GJ Yoon, HJ Jeong, JS Choi, SJ Hwang, JW Kim, BG Min, “Development and Evaluation of a Novel Electro-mechanical Implantable Ventricular Assist System,” J. Biomed. Eng. Res. 2001; 22:349-358 

J.H. Lee, J.M. Jang, H. Cho, T. Kim, E.G. Yang, “Development of High-Throughput Screening Systems for RNA Targets Using Microfluidic Chips,” International women’s conference on BIEN-technology, Daejeon, Korea, Nov. 13-16, 2003:218

H. Cho, B.C. Chang, S. Kim, D. Min, G.J. Yoon, J. Kim, “Further Development of the Cylindrical Cam Type IVAD as a Clinical Model,” ASAIO (American Society of Artificial Organs) J. 2002; 48:162

S.S. Cheon, H. Cho, M.H. Ryu, J. Kim, “Development of a Pump Output Estimation Algorithm Using Motor Current for a Pulsatile Implantable IVAD,” ASAIO J 2002; 48:161

S.H. Lim, B.C. Chang, Y.S. Hong, H. Cho, “Preliminary Result of Thrombosis and Hemolysis in Biomedlab Implantable Ventricular Assist Device”, ASAIO J 2002; 48:140

H. Cho, W.G. Kim, J.S. Choi, B.S. Soo, E.S. Ryu, G.J. Yoon, M.H. Ryu, J. Kim, B.G. Min, “Development of Implantable Ventricular Assist System with a Cylindrical Cam,” ASAIO J 2001; 47:145

M.H. Ryu, J.S. Choi, H. Cho, G.J. Yoon, J. Kim, B.G. Min, “An Automatic Driving Method for a Pulsatile Implantable Ventricular Assist Device”, ASAIO J 2001; 47:142

H. Cho, W. Kim, G.J. Yoon, M.H. Ryu, B.S. Soo, J. Kim, “Development of an implantable ventricular assist system with a double cylindrical cam,” Int. J. Artificial Organs 2001; 25:790

H. Cho, W.W. Choi, B.S. Soo, G.J. Yoon, H.J. Yu, J.K. Kim, M.S. Kim, M.S. Park, S.M. Kwak, J. Kim, B.G. Min, “Development of a New Implantable Ventricular Assist Device,” ASAIO J 2000; 46:204

H. Cho, K.S. Om, H.S. Lee, J.H. Chung, B.G. Min, “Flow Modeling Around Prosthetic Heart Valve Using Pressure Difference,” the 4th Asia-pacific Conference on medical & biological conference, Seoul, Korea, Sep. 12-15, 1999; 4:251 (oral presentation)

K.S. Om, J.M. Ahn, C.Y. Park, G.J. Yun, H. Cho, J. Kim, Y.H. Jo, W.E. Kim, Y.N. Park, J.S. Choi, J.W. Park, S.W. Choi, W.K. Kim, and B.G. Min, “The Automatic Control of the Moving-Actuator Type Totally-Implantable Artificial Heart Using the Motor Current,” the 4th Asia-pacific Conference on medical & biological engineering, Seoul, Korea, Sep. 12-15, 1999; 4:239